Millions for a Life-Saving Dose? Here are America’s Most Expensive Drugs in 2025 - Voronoi
Oct 17, 2025
Millions for a Life-Saving Dose? Here are America’s Most Expensive Drugs in 2025
Key Takeaways
A single dose of Lenmeldy (which treats kids with metachromatic leukodystrophy, MLD) costs $4.25 million dollars, America’s most expensive medication in 2025.
This is approximately the same price as 12,500 Ozempic doses (at $342 each, without insurance).
However, Lenmeldy, and all of the other top 10 most expensive medications are one-time gene or tissue therapies.
Their expensive price tag stems from two reasons: it’s a once-in-a-lifetime medication (so no repeated doses), and the disorders they treat are so rare that often each dose is custom made for the recipient, driving up costs.
And when it can be administered is also tricky. Per the source, many patients with MLD were not eligible for Lenmeldy due to how much their disease had progressed already.
