Millions for a Life-Saving Dose? Here are America’s Most Expensive Drugs in 2025

Key Takeaways

• A single dose of Lenmeldy (which treats kids with metachromatic leukodystrophy, MLD) costs $4.25 million dollars, America’s most expensive medication in 2025.
• This is approximately the same price as 12,500 Ozempic doses (at $342 each, without insurance).
• However, Lenmeldy, and all of the other top 10 most expensive medications are one-time gene or tissue therapies.
• Their expensive price tag stems from two reasons: it’s a once-in-a-lifetime medication (so no repeated doses), and the disorders they treat are so rare that often each dose is custom made for the recipient, driving up costs.
• And when it can be administered is also tricky. Per the source, many patients with MLD were not eligible for Lenmeldy due to how much their disease had progressed already.